Product Type	Quantitative ELISA, Colorimetric
Product Summary	Assay Range: 62.5-4000 pg/mL Sensitivity: 30 pg/mL Sample Types: Serum, Plasma, Cell Culture Supernates Intra-Assay Precision: ≤10% Inter-Assay Precision: ≤15%
Reactivity	Human G-CSF No cross-reactivity with human cytokines
Product Components	Human G-CSF Coated Microplate, 96 well (8 x12 strips) Human G-CSF Standard, 2 vials Human G-CSF Biotinylated Antibody, 2 vials Streptavidin-HRP, 2 vials Dilution Buffer, 3 bottles Washing Buffer, 1bottle Color Reagent (TMB), 1 bottle Stop Solution, 1 bottle Plate Sealers, 4 strips Other materials required: See Datasheet

Shipping	Shipped on blue ice
Stability & Storage	Store the unopened kit at 2-8℃, The kit is stable for 12 months. Do not use beyond expiration date.
Reconstitution	See Datasheet for Component Preparation

Alternative Names	Granulocyte Colony Stimulating Factor, Colony Stimulating Factor 3GCSF, CSF3, C17orf33, CSF3OS, Filgrastim, Pluripoietin, Lenograstim
Function	G-CSF primarily stimulates the proliferation, differentiation, and survival of neutrophilic granulocyte precursors in the bone marrow and stimulates upregulation of mature neutrophil release into the bloodstream as part of the innate immune response. During an immune response, G-CSF is secreted by monocytes, macrophages, and activated T cells. G-CSF binds to the G-CSF receptor (G-CSFR), which is expressed on the surface of hematopoietic cells, particularly myeloid progenitors. G-CSF signaling occurs via the JAK/STAT, Ras/MAPK and PI3K/Akt pathways.
Tissue Specificity	G-CSF expression has been reported in bone marrow stromal cells, fibroblasts, endothelial cells, and epithelial cells.
Cellular Localization	Secreted protein
Involvement in Disease	Dysregulation of G-CSF is implicated in leukemias (such as acute myeloid leukemia) and myelodysplastic syndromes, autoimmune disorders (rheumatoid arthritis and inflammatory bowel disease), congenital neutropenia, and solid tumors where aberrant expression may contribute to tumor progression, metastasis, and the formation of a supportive tumor microenvironment.
UniProt	P09919-2
Gene Symbol	CSF3
Entrez Gene ID	1440

Human G-CSF Precoated ELISA Kit

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