Product Type	Quantitative ELISA, Colorimetric
Product Summary	Assay Range: 31.3-2000 pg/mL Sensitivity: 15 pg/mL Sample Types: Serum, Plasma, Cell Culture Supernates Intra-Assay Precision: ≤10% Inter-Assay Precision: ≤15%
Reactivity	Human IL-21 No cross-reactivity with human cytokines
Product Components	Human IL-21 Coated Microplate, 96 well (8 x12 strips) Human IL-21 Standard, 2 vials Human IL-21 Biotinylated Antibody, 2 vials Streptavidin-HRP, 2 vials Dilution Buffer, 3 bottles Washing Buffer, 1bottle Color Reagent (TMB), 1 bottle Stop Solution, 1 bottle Plate Sealers, 4 strips Other materials required: See Datasheet

Shipping	Shipped on blue ice
Stability & Storage	Store the unopened kit at 2-8℃, The kit is stable for 12 months. Do not use beyond expiration date.
Reconstitution	See Datasheet for Component Preparation

Alternative Names	Interleukin 21, Za11, CVID11
Function	Interleukin-21 (IL-21) is a cytokine that plays a role in coordinating immune responses and maintaining immune system balance. IL-21 is produced by NKT cells, Th17 cells and T follicular helper cells (Tfh). It functions in downregulating regulatory T (Treg) cells and modulating B cell activation and differentiation into plasma cells and memory B cells. Through the stimulation of NK cells and CD8 T cells, IL-21 is associated with antitumor activity. IL-21 signaling occurs through the heterodimer receptor complex of IL-21R (CD360) and the common gamma chain (CD132).
Tissue Specificity	IL-21 expression has been identified in spleen, lymph nodes, tonsils, thymus, gut-associated lymphoid tissue (GALT), mucosa-associated lymphoid tissue (MALT), skin, and liver.
Cellular Localization	Secreted protein
Involvement in Disease	Dysregulation of IL-21 is associated with autoimmune disorders (rheumatoid arthritis, systemic lupus erythematosus (SLE), inflammatory bowel disease (IBD)), asthma, allergic rhinitis, psoriasis, and atopic dermatitis.
UniProt	Q9HBE4
Gene Symbol	IL21
Entrez Gene ID	59067

Human IL-21 Precoated ELISA Kit

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