Human IL-23 Precoated ELISA Kit
$499.00
Out of stock
In-stock products will arrive in 1 to 2 business days.
For Research Use Only.
Not Intended for Diagnostic or Therapeutic Use.
Key Features
✓ Assay Range: 15.6-1000 pg/mL
✓ Sensitivity: 8 pg/mL
✓ Sample Types: Serum, Plasma, Cell Culture Supernates
Size
✓ 1 Kit (96 well plate)
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Product Details
Storage & Preparation
Data Images
Background
Product Documents
Product Details
| Product Type | Quantitative ELISA, Colorimetric |
| Product Summary |
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| Reactivity | Human IL-23
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| Product Components |
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Storage & Preparation
| Shipping | Shipped on blue ice |
| Stability & Storage | Store the unopened kit at 2-8℃, The kit is stable for 12 months. Do not use beyond expiration date. |
| Reconstitution | See Datasheet for Component Preparation |
Data Images
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| Human IL-23 ELISA standard curve, typical data. User-generated standard curve is required for each set of samples. Please refer to protocol. |
Background
| Alternative Names | Interleukin 23, IL-23p19, alpha subunit p19, P19, JKA3 induced upon T-cell activation |
| Function | IL-23 is important in maintaining the balance of immune tolerance and activation, influencing both the innate and adaptive immune systems. IL-23 also stimulates the production of other cytokines like IL-17 and IL-22, which further amplify inflammation and immune responses. IL-23 is a heterodimeric cytokine, composed of two subunits: the p19 subunit and the p40 subunit. The p19 subunit is unique to IL-23, while the p40 subunit is shared with IL-12. IL-23 signals through the IL-23 receptor (IL-23R), which is composed of two subunits: the IL-23R and the IL-12Rβ1 subunit. Upon binding of IL-23 to its receptor, the associated Janus kinase (JAK) family members, JAK2 and TYK2, are activated. This leads to the phosphorylation of signal transducers and activators of transcription (STAT) proteins, particularly STAT3. |
| Tissue Specificity | IL-23 expression has been reported in skin, intestinal tissue, lung tissue, synovial tissue as well as dendritic cells, macrophages, monocytes, epithelial cells, T cells and fibroblasts. |
| Cellular Localization | Secreted protein |
| Involvement in Disease | Dysregulation of IL-23 is implicated in psoriasis, rheumatoid arthritis, inflammatory bowel disease, ankylosing spondylitis, multiple sclerosis, systemic lupus erythematosus, asthma, chronic obstructive pulmonary disease (COPD), vitiligo, uveitis, and cancer (colorectal and melanoma). |
| UniProt | Q9NPF7 |
| Gene Symbol | IL23A |
| Entrez Gene ID | 51561 |
Product Documents
| Product Datasheet | Download Product Datasheet |
| COA | Contact Us |
| SDS | Contact Us |
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