Human IL-5 Precoated ELISA Kit
$499.00
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Key Features
✓ Assay Range: 3.9-250 pg/mL
✓ Sensitivity: 2 pg/mL
✓ Sample Types: Serum, Plasma, Cell Culture Supernates
Size
✓ 1 Kit (96 well plate)
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Product Details
Storage & Preparation
Data Images
Background
Product Documents
Product Details
| Product Type | Quantitative ELISA, Colorimetric |
| Product Summary |
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| Reactivity | Human IL-5
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| Product Components |
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Storage & Preparation
| Shipping | Shipped on blue ice |
| Stability & Storage | Store the unopened kit at 2-8℃, The kit is stable for 12 months. Do not use beyond expiration date. |
| Reconstitution | See Datasheet for Component Preparation |
Data Images
Human IL-5 ELISA standard curve, typical data. User-generated standard curve is required for each set of samples. Please refer to protocol.
Background
| Alternative Names | Interleukin 5, B-cell differentiation factor I, BCDF mu, BCGFII, Eosinophil differentiation factor, EDF, Eo-CSF, T-cell replacing factor, TRF, ILN |
| Function | Interleukin-5 (IL-5) is a cytokine primarily involved in the regulation of eosinophil development, differentiation, activation, and survival. It is key in orchestrating immune responses, particularly in allergic reactions, asthma, and parasitic infections. IL-5 plays a critical role in eosinophil production in the bone marrow and their subsequent release into the peripheral blood, where they accumulate at sites of inflammation. Additionally, IL-5 promotes the activation of eosinophils, enhancing their ability to release pro-inflammatory mediators. IL-5 is a glycoprotein that belongs to the IL-5/IL-3/GM-CSF cytokine family, sharing structural similarities with IL-3 and GM-CSF. IL-5 exerts its biological effects through binding to the IL-5 receptor (IL-5R), a heterodimeric receptor complex composed of two subunits: the IL-5Rα (alpha) subunit, which is specific for IL-5, and the common β (beta) chain shared with other cytokine receptors like IL-3 and GM-CSF. Upon IL-5 binding to the IL-5Rα, a conformational change occurs, leading to recruitment of the signaling component, the β chain. This activation triggers downstream signaling pathways, primarily involving the JAK/STAT pathway. |
| Tissue Specificity | IL-5 expression has been reported in spleen and lung tissue, bone marrow, T-helper 2 (Th2) and Mast cells |
| Cellular Localization | Secreted protein |
| Involvement in Disease | Dysregulation of IL-5 is associated with asthma, particularly in eosinophilic asthma, eosinophilic esophagitis (EoE), allergic rhinitis, chronic rhinosinusitis with nasal polyps (CRSwNP), atopic dermatitis (eczema), parasitic infections, such as helminth, and celiac disease. |
| UniProt | P05113 |
| Gene Symbol | IL5 |
| Entrez Gene ID | 3567 |
Product Documents
| Product Datasheet | Download Product Datasheet |
| COA | Contact Us |
| SDS | Contact Us |
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