Recombinant Human IL-13 Protein (EXRP044)
Price range: $90.00 through $5,700.00
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For Research Use Only.
Not Intended for Diagnostic or Therapeutic Use.
Key Features
✓ Endotoxin Level: <0.005 EU/1ug
✓ Purity: >97% SDS-PAGE
✓ Biological Activity: Yes
✓ Expression System: E. coli
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Product Details
Storage & Preparation
Data Images
Background
Product Documents
Product Details
| Biological Activity | Determined by a cell proliferation assay using human TF-1 cells. The ED50 for this effect is typically <2 ng/mL. |
| Purity | Determined by SDS-PAGE and quantitative densitometry by Coomassie® Blue staining |
| Endotoxin | Determined by LAL method |
| Expression System | E. coli. |
| Accession Number | P35225 |
| Sequence | Ser19-Asn132, with an N-terminal Met
MSPGPVPPST ALRELIEELV NITQNQKAPL CNGSMVWSIN LTAGMYCAAL ESLINVSGCS AIEKTQRMLS GFCPHKVSAG QFSSLHVRDT KIEVAQFVKD LLLHLKKLFR EGRFN |
| Molecular Weight | 12.7 kDa (predicted) |
| Formulation | Lyophilized from sterile PBS with Trehalose, pH 7.4 |
Storage & Preparation
| Shipping | Shipped at ambient temperature. |
| Stability & Storage |
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| Reconstitution | Reconstitute at 100 ug/mL in sterile PBS. |
Data Images
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 |
| Determined by a cell proliferation assay using human TF-1 cells.
The ED50 for this effect is typically <2 ng/mL. |
Recombinant Human IL-13 (2 μg/lane) on SDSPAGE under reducing (R) conditions. The gel was stained using Coomassie® Blue showing a single band at 15 kDa and purity greater than 98%. and purity greater than 98%. |
Background
| Alternative Names | Interleukin 13, IL13, P600, NC30, MGC116786, MGC116788, MGC116789 |
| Function | Interleukin-13 (IL-13) is a cytokine primarily produced by T helper type 2 (Th2) cells, as well as other immune cells like mast cells, basophils, and eosinophils. It promotes the activation, differentiation, and survival of B cells, including Ig class switching. IL-13 enhances the survival and migration of epithelial cells in various organs, coupling this with its anti-parasitic Th2-mediated response in these organs. IL-13 signaling occurs when it binds IL13RA1 (CD213A1) which heterodimerizes with IL-4R alpha (CD124) to activate the JAK/STAT signal pathway. |
| Tissue Specificity | IL-13 expression has been identified in gastrointestinal and lung epithelial tissue. |
| Cellular Localization | Secreted protein |
| Involvement in Disease | Dysregulation of IL-13 is associated with asthma, allergic rhinitis, atopic dermatitis, scleroderma, inflammatory bowel disease (IBD), and allergic conjunctivitis. |
| UniProt | P35225 |
| Gene Symbol | IL13 |
| Entrez Gene ID | 3596 |
Product Documents
| Product Datasheet | Download Product Datasheet |
| COA | Contact Us |
| SDS | Download SDS |
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