Recombinant Human IL-4 Protein (EXRP014)
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Key Features
✓ Endotoxin Level: <0.001 EU/1ug
✓ Purity: >97% SDS-PAGE
✓ Biological Activity: Yes
✓ Expression System: E. coli
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Product Details
Storage & Preparation
Data Images
Background
Product Documents
Product Details
| Biological Activity | Determined by a cell proliferation assay using human TF-1 cells. The ED50 for this effect is typically <100 pg/mL. |
| Purity | >97% by SDS-PAGE and quantitative densitometry by Coomassie® Blue staining. |
| Endotoxin | <0.001 EU/1ug of the protein as determined by the LAL method. |
| Expression System | E. coli. |
| Accession Number | P05112 |
| Sequence | His25-Ser153, with an N-terminal Met
MHKCDITLQE IIKTLNSLTE QKTLCTELTV TDIFAASKNT TEKETFCRAA TVLRQFYSHH EKDTRCLGAT AQQFHRHKQL IRFLKRLDRN LWGLAGLNSC PVKEANQSTL ENFLERLKTI MREKYSKCSS |
| Molecular Weight | 15.1 kDa (monomer, predicted) |
| Formulation | Lyophilized from sterile PBS with Trehalose, pH 7.4 |
Storage & Preparation
| Shipping | Shipped at ambient temperature. |
| Stability & Storage |
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| Reconstitution | Reconstitute at 100 ug/mL in sterile PBS. |
Data Images
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| Determined by a cell proliferation assay using human TF-1 cells. The ED50 for this effect is typically <100 pg/mL. | Recombinant Human IL-4 (2 ug/lane) on SDS-PAGE under reducing (R) conditions. The gel was stained using Coomassie® Blue showing a single band at 15 kDa and purity greater than 97%. |
Background
| Alternative Names | Interleukin 4, Lymphocyte Stimulatory Factor 1, B-Cell Stimulatory Factor 1, B Cell Growth Factor 1, BCGF1, BSF1, Binetrakin, Pitrakinra, MGC79402, IL4e12, IgG1 Induction Factor |
| Function | Interleukin-4 (IL-4) is a cytokine involved in the regulation of immune and inflammatory responses. It promotes the differentiation of naïve T cells into Th2 cells, which in turn stimulate B cells to upregulate IgE antibodies. IL-4 is produced by mast cells, eosinophils, basophils and committed Th2 cells. There are two cell-dependent receptor complexes, either a heterodimer of IL-4 R alpha (CD124) and the common gamma chain (CD132) associated with hematopoietic cells or a heterodimer of IL-4 R alpha and IL-13 R alpha 1 (CD213A1) associated with non-hematopoietic cells. |
| Tissue Specificity | IL-4 expression has been identified in lymph node and placenta. |
| Cellular Localization | Secreted protein |
| Involvement in Disease | Allergic inflammation, allergic rhinitis, asthma, atopic dermatitis, autoimmune disorders (rheumatoid arthritis, systemic lupus erythematosus (SLE), and multiple sclerosis), inflammatory bowel disease (IBD) and graft-versus-host disease (GVHD). |
| UniProt | P05112 |
| Gene Symbol | IL4 |
| Entrez Gene ID | 3565 |
Product Documents
| Product Datasheet | Download Product Datasheet |
| COA | Contact Us |
| SDS | Download SDS |
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