Recombinant Human FGF-10 Protein (EXRP005)
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Key Features
✓ Endotoxin Level: <0.02 EU/1ug
✓ Purity: 95% SDS-PAGE
✓ Biological Activity: Yes
✓ Expression System: E. coli
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Product Documents
Product Details
| Biological Activity | Determined by a cell proliferation assay using 4MBr-5 rhesus monkey cells. The ED50 for this effect is typically 10-75 ng/mL. |
| Purity | >95% by SDS-PAGE and quantitative densitometry by Coomassie® Blue staining. |
| Endotoxin | <0.02 EU per 1 ug of the protein as determined by the LAL method. |
| Expression System | E. coli. |
| Accession Number | O15520 |
| Sequence | Cys37-Ser208, with an N-terminal Met
MCQALGQDMV SPEATNSSSS SFSSPSSAGR HVRSYNHLQG DVRWRKLFSF TKYFLKIEKN GKVSGTKKEN CPYSILEITS VEIGVVAVKA INSNYYLAMN KKGKLYGSKE FNNDCKLKER IEENGYNTYA SFNWQHNGRQ MYVALNGKGA PRRGQKTRRK NTSAHFLPMV VHS |
| Molecular Weight | 19.6 kDa (predicted) |
| Formulation | Lyophilized from sterile PBS with Trehalose, DTT, and EDTA, pH 7.4 |
Storage & Preparation
| Shipping | Shipped at ambient temperature. |
| Stability & Storage |
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| Reconstitution | Reconstitute at 25 µg/mL in sterile PBS with 0.1% BSA. |
Data Images
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| Determined by a cell proliferation assay using 4MBr-5 rhesus monkey cells. The ED50 for this effect is typically 10-75 ng/mL. | Recombinant Human FGF-10 (2 ug/lane) on SDS-PAGE under reducing (R) conditions. The gel was stained using Coomassie® Blue showing a single band at 20 kDa and purity greater than 95%. Note: Coomassie Blue staining with this protein is weaker than expected. |
Background
| Alternative Names | Fibroblast Growth Factor 10, Keratinocyte Growth Gactor 2, KGF2 |
| Function | Fibroblast Growth Factor 10 (FGF-10) is a protein involved in various developmental processes, particularly in embryogenesis and tissue regeneration. FGF-10 promotes branching morphogenesis of branched structures in several organs, including lungs, salivary glands, skin, pancreas, and mammary glands. Additionally, FGF-10 stimulates angiogenesis in during embryonic development, the maintenance of stem cell populations and facilitates tissue repair. FGF-10 primarily binds to FGF Receptor 2B (FGFR2B). |
| Tissue Specificity | Lungs, salivary glands, skin, pancreas, inner ear, prostate and mammary glands. |
| Cellular Localization | Secreted protein |
| Involvement in Disease | Aberrant FGF-10 signaling has been implicated in several lung diseases, including pulmonary fibrosis, chronic obstructive pulmonary disease (COPD), and lung cancer. Dysregulated FGF-10 expression or signaling pathways can disrupt lung development and repair processes. Elevated FGF-10 expression or aberrant activation of FGF receptors (FGFRs) have been implicated in pancreatic, breast and prostate cancer tumor growth and metastasis. |
| UniProt | O15520 |
| Gene Symbol | FGF10 |
| Entrez Gene ID | 2255 |
Product Documents
| Product Datasheet | Download Product Datasheet |
| COA | Contact Us |
| SDS | Download SDS |
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