Recombinant Human Flt-3 Ligand/FLT3L Protein (EXRP029)
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For Research Use Only.
Not Intended for Diagnostic or Therapeutic Use.
Key Features
✓ Endotoxin Level: <0.1 EU/1ug
✓ Purity: >97% SDS-PAGE
✓ Biological Activity: Yes
✓ Expression System: E. coli
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Product Details
Storage & Preparation
Data Images
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Product Documents
Product Details
| Biological Activity | Determined by a cell proliferation assay using human THP-1 cells. The ED50 for this effect is typically < 3 ng/mL. |
| Purity | >97% by SDS-PAGE and quantitative densitometry by Coomassie® Blue staining |
| Endotoxin | <0.1 EU/1ug of the protein as determined by the LAL method. |
| Expression System | E. coli. |
| Accession Number | P49771.1 |
| Sequence | Thr27-Ala181, with an N-terminal Met
MTQDCSFQHS PISSDFAVKI RELSDYLLQD YPVTVASNLQ DEELCGGLWR LVLAQRWMER LKTVAGSKMQ GLLERVNTEI HFVTKCAFQP PPSCLRFVQT NISRLLQETS EQLVALKPWI TRQNFSRCL E LQCQPDSSTL PPPWSPRPLE ATAPTA |
| Molecular Weight | 17.8 kDa (monomer, predicted) |
| Formulation | Lyophilized from sterile PBS with Trehalose, pH 7.4 |
Storage & Preparation
| Shipping | Shipped at ambient temperature. |
| Stability & Storage |
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| Reconstitution | Reconstitute at 100 ug/mL in sterile PBS. |
Data Images
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| Determined by a cell proliferation assay using human THP-1 cells. The ED50 for this effect is typically < 3 ng/mL. | Recombinant Human Flt-3 Ligand (2 ug/lane) on SDS-PAGE under reducing (R) conditions. The gel was stained using Coomassie® Blue showing a single band at 17 kDa and purity greater than 97%. |
Background
| Alternative Names | fms-like Tyrosine Kinase 3 Ligand, FLT3L, Flt3 Ligand, FLG3L, SL Cytokine |
| Function | Flt-3L (Fms-related tyrosine kinase 3 ligand) is a protein that plays a role in regulating the survival, expansion and differentiation of hematopoietic stem cells (HSCs), including progenitor cells in both the lymphoid and myeloid lineages. Flt-3L also promotes expansion and differentiation of dendritic cells, NK cells and B cells. Flt-3L is expressed as both membrane-bound and soluble isoforms, both of which initiate signaling through binding to the receptor, Flt3 (CD135/Flk2). |
| Tissue Specificity | Flt-3L expression has been reported in bone marrow stromal cells, brain, thymus, placenta, spleen, testes, and lymph nodes. |
| Cellular Localization | Membrane-bound and cleaved soluble protein forms |
| Involvement in Disease | Dysregulation of Flt-3L is associated with aplastic anemia and acute myeloid leukemia. |
| UniProt | P49771 |
| Gene Symbol | FLT3LG |
| Entrez Gene ID | 2323 |
Product Documents
| Product Datasheet | Download Product Datasheet |
| COA | Contact Us |
| SDS | Download SDS |
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