Recombinant Human KGF/FGF-7 Protein (EXRP015)
$69.00 – $5,139.00
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Key Features
✓ Endotoxin Level: <0.001 EU/1ug
✓ Purity: >97% SDS-PAGE
✓ Biological Activity: Yes
✓ Expression System: E. coli
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Product Details
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Data Images
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Product Documents
Product Details
| Biological Activity | Determined by a cell proliferation assay using 4MBr-5 rhesus monkey cells. The ED50 for this effect is typically < 3 ng/mL. |
| Purity | >97% by SDS-PAGE and quantitative densitometry by Coomassie® Blue staining |
| Endotoxin | <0.001 EU/1ug of the protein as determined by the LAL method. |
| Expression System | E. coli. |
| Accession Number | P21781 |
| Sequence | Cys32-Thr194, with an N-terminal Met
MCNDMTPEQM ATNVNCSSPE RHTRSYDYME GGDIRVRRLF CRTQWYLRID KRGKVKGTQE MKNNYNIMEI RTVAVGIVAI KGVESEFYLA MNKEGKLYAK KECNEDCNFK ELILENHYNT YASAKWTHNG GEMFVALNQK GIPVRGKKTK KEQKTAHFLP MAIT |
| Molecular Weight | 19 kDa (monomer, predicted) |
| Formulation | Lyophilized from sterile PBS with Trehalose, pH 7.4 |
Storage & Preparation
| Shipping | Shipped at ambient temperature. |
| Stability & Storage |
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| Reconstitution | Reconstitute at 100 ug/mL in sterile PBS. |
Data Images
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| Determined by a cell proliferation assay using 4MBr-5 rhesus monkey cells. The ED50 for this effect is typically < 3 ng/mL. |
Recombinant Human KGF/FGF-7 (2 ug/lane) on SDSPAGE under reducing (R) conditions. The gel was stained using Coomassie® Blue showing a major band at 19 kDa and purity greater than >97%. |
Background
| Alternative Names | Keratinocyte Growth Factor, Fibroblast Growth Factor 7, KGF, FGF7, Heparin-Binding Growth Factor 7, HBGF-7 |
| Function | Keratinocyte growth factor (KGF), also known as fibroblast growth factor 7 (FGF-7) plays a role in embryonic development, cell proliferation, tissue repair, branching morphogenesis, and tumor progression. KGF is primarily expressed in mesenchymal cells, specifically in tissues where epithelial-mesenchymal interactions occur. As such, KGF activity is mainly exhibited on epithelial cells, particularly keratinocytes, by influencing the repair and regeneration of damaged epithelial tissues, facilitating wound healing processes and promoting pathways to protect epithelial cells from UV radiation and toxins. Additionally, KGF is involved in the development and maintenance of hair follicles, promoting hair growth. In cell culture, KGF has efficacy in the differentiation of pluripotent stem cells (PSCs) toward thymic epithelial cells and in the culture of 3-D organoids. The receptor KGF is FGFR2IIIb. |
| Tissue Specificity | KGF has been detected in mesenchymal cells in skin, lung, intestine, salivary glands, and bladder. |
| Cellular Localization | Secreted protein |
| Involvement in Disease | Dysregulation of KGF is associated with psoriasis, gingival hyperplasia, idiopathic pulmonary fibrosis (IPF), inflammatory bowel disease (IBD), mucositis, interstitial cystitis, and tumorigenesis in stomach, colon, pancreas, and ovarian cancers. |
| UniProt | P21781 |
| Gene Symbol | FGF7 |
| Entrez Gene ID | 2252 |
Product Documents
| Product Datasheet | Download Product Datasheet |
| COA | Contact Us |
| SDS | Download SDS |
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