Recombinant Human PDGF-AA Protein (EXRP050)
Price range: $90.00 through $4,199.00
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For Research Use Only.
Not Intended for Diagnostic or Therapeutic Use.
Key Features
✓ Endotoxin Level: Determined by LAL method
✓ Purity: Determined by SDS-PAGE and quantitative densitometry by Coomassie® Blue staining
✓ Biological Activity: Yes
✓ Expression System: E. coli
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Product Details
Storage & Preparation
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Product Documents
Product Details
| Biological Activity | Determined by in-house activity assay |
| Purity | Determined by SDS-PAGE and quantitative densitometry by Coomassie® Blue staining |
| Endotoxin | Determined by LAL method |
| Expression System | E. coli. |
| Accession Number | P04085 |
| Sequence | Ser87-Thr211 SIEEAVPAVC KTRTVIYEIP RSQVDPTS AN FLIWPPCVEV KRCTGCCNTS SVKCQPSRVH HRSVKVAKVE YVRKKPKLKE VQVRLEEHLE CACATTSLNP DYREEDTGRP RESGKKRKRK RLKPT |
| Molecular Weight | 14.3 kDa (monomer, predicted) |
| Formulation | Lyophilized from sterile PBS with Trehalose, pH 7.4 |
Storage & Preparation
| Shipping | Shipped at ambient temperature. |
| Stability & Storage |
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| Reconstitution | Reconstitute at 100 ug/mL in sterile PBS. |
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| Alternative Names | Platelet-derived Growth Factor AA, Platelet Derived Growth Factor Subunit A, Platelet Derived Growth Factor A Chain, Platelet Derived Growth Factor Alpha Chain, Platelet Derived Growth Factor Alpha Polypeptide, PDGF Subunit A, PDGF A-Chain, PDGF1 |
| Function | Platelet-Derived Growth Factor AA (PDGF-AA) is a protein with roles in regulating of many processes including embryonic development, angiogenesis, cell proliferation and differentiation. PDGF-BB acts on mesenchymal cells as a mitogen for connective tissue formation, particularly fibroblasts, vascular smooth muscle cells and glial cells. PDGF-AA is present in the alpha granules of platelets. As such, PDGF-AA promotes angiogenesis, chemotaxis of fibroblasts and collagen synthesis in tissue repair. Additionally, PDGF-AA supports development of kidney glomeruli, the differentiation of neural stem cells and has neuroprotective functions on mature neurons during injury. PDGF-AA binds to the PDGFR alpha (CD140a) homodimer only and activates the MAPK, PI3K, and STAT3 pathways. |
| Tissue Specificity | PDGF-AA expression has been identified in epithelial tissue, endothelial tissue, smooth muscle tissue, colon, heart, lung, brain and neurons. |
| Cellular Localization | Secreted protein |
| Involvement in Disease | Dysregulation of PDGF-AA is associated with atherosclerosis, pulmonary hypertension, glomerulonephritis, diabetic retinopathy, keloids, hypertrophic scars, cancer (glioma, sarcoma, and tumor angiogenesis). |
| UniProt | P04085 |
| Gene Symbol | PDGFA |
| Entrez Gene ID | 5154 |
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