Recombinant Human VEGF 165 Protein (EXRP021)
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Key Features
✓ Endotoxin Level: <0.001 EU/1ug
✓ Purity: >98% SDS-PAGE
✓ Biological Activity: Yes
✓ Expression System: E. coli
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Data Images
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Product Documents
Product Details
| Biological Activity | Determined by a cell proliferation assay using HUVEC human umbilical vein endothelial cells. The ED50 for this effect is typically 1-5 ng/mL. |
| Purity | >98% by SDS-PAGE and quantitative densitometry by Coomassie® Blue staining. |
| Endotoxin | <0.001 EU/1ug (<1 EU/mg) of the protein as determined by the LAL method. |
| Expression System | E. coli. Disulfide-linked homodimer |
| Accession Number | NP_001165097.1 |
| Sequence | Ala27-Arg191
APMAEGGGQN HHEVVKFMDV YQRSYCHPIE TLVDIFQEYP DEIEYIFKPS CVPLMRCGGC CNDEGLECVP TEESNITMQI MRIKPHQGQH IGEMSFLQHN KCECRPKKDR ARQENPCGPC SERRKHLFVQ DPQTCKCSCK NTDSRCKARQ LELNERTCRC DKPRR |
| Molecular Weight | 19.2 kDa (monomer, predicted) |
| Formulation | Lyophilized from sterile HEPES and NaCl with Trehalose, pH 7.4 |
Storage & Preparation
| Shipping | Shipped at ambient temperature. |
| Stability & Storage |
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| Reconstitution | Reconstitute at 100 ug/mL in sterile PBS. |
Data Images
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| Determined by a cell proliferation assay using HUVEC human umbilical vein endothelial cells. The ED50 for this effect is typically 1-5 ng/mL. | Recombinant Human VEGF 165 (2 ug/lane) on SDS-PAGE under reducing (R) and non-reducing (NR) conditions. The gel was stained using Coomassie® Blue showing single bands at 20 kDa (R) and 39 kDa (NR), and purity greater than 98%. |
Background
| Alternative Names | Vascular Endothelial Growth Factor, VEGF-A, Vascular Permeability Factor, VPF, MVCD1 |
| Function | Vascular endothelial growth factor (VEGF) is involved in angiogenesis, vasculogenesis, neurogenesis and endothelial cell growth during embryonic development and in adults. It induces endothelial cell proliferation, migration, and permeabilization of blood vessels. VEGF is upregulated during hypoxia, inflammation, tissue repair and during neovascularization of tumors and adipose tissue. Additionally, VEGF induces neural progenitor cell proliferation and regulates mesenchymal stem cell differentiation. VEGF binds to the VEGFR1 (FLT1) and VEGFR2 (KDR/CD309) receptors, however, Neuropilin-1 will also bind VEGF as a coreceptor for VEGFR2. |
| Tissue Specificity | VEGF expression has been reported in vascular endothelial cells, ovaries, adipose tissue, skeletal muscle and most tumors. |
| Cellular Localization | Secreted protein |
| Involvement in Disease | VEGF dysregulation is implicated in macular degeneration, diabetic retinopathy, rheumatoid arthritis, psoriasis, and cancer. |
| UniProt | P15692 |
| Gene Symbol | VEGFA |
| Entrez Gene ID | 7422 |
Product Documents
| Product Datasheet | Download Product Datasheet |
| COA | Contact Us |
| SDS | Download SDS |
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